Mounjaro Users' Weight-Loss Plateau Spells Trouble: Study Reveals Reversal of Health Benefits Upon Dose Cessation.
Researchers have discovered that individuals who discontinue using the weight-loss medication Mounjaro experience not only a rebound in weight, but also a reversal of other health benefits they had achieved during treatment. The biotech giant Eli Lilly's top-selling medication has been touted for its remarkable ability to facilitate significant body weight reductions - up to 20% - following 72-week treatment.
A study published recently in the journal Jama Internal Medicine analyzed data from participants who initially experienced substantial weight loss while undergoing Mounjaro treatment, alongside diet and exercise support. The trial involved 308 patients who lost at least 10% of their body weight over a 36-week period before switching to a placebo for an additional 52 weeks.
Surprisingly, the findings revealed that nearly 82% of participants regained 25% or more of their initial weight reduction just one year after stopping Mounjaro. Furthermore, greater weight regain was associated with a notable reversal in other health benefits, including waist circumference, levels of "bad" cholesterol, blood pressure, and blood glucose levels.
"The findings are not surprising, as excess weight is a well-established driver of elevated blood pressure and impaired glucose control," noted Naveed Sattar, professor of cardiometabolic medicine at the University of Glasgow. "Consequently, when weight lost through therapeutic interventions is regained, these cardiometabolic risk factors typically rise in proportion to the speed and extent of weight regain."
The study emphasizes the importance of long-term maintenance of weight reduction through lifestyle intervention and obesity management medications to sustain cardiometabolic benefits and improved health-related quality of life. It also highlights the potential risks of relying solely on medication for weight loss, particularly when it can lead to poorer dietary habits and a lack of motivation to engage in regular physical activity.
While researchers acknowledge that further trials are necessary to confirm these findings, they underscore the need for caution and careful consideration when interpreting data related to weight-loss medications and their effects on health.
Researchers have discovered that individuals who discontinue using the weight-loss medication Mounjaro experience not only a rebound in weight, but also a reversal of other health benefits they had achieved during treatment. The biotech giant Eli Lilly's top-selling medication has been touted for its remarkable ability to facilitate significant body weight reductions - up to 20% - following 72-week treatment.
A study published recently in the journal Jama Internal Medicine analyzed data from participants who initially experienced substantial weight loss while undergoing Mounjaro treatment, alongside diet and exercise support. The trial involved 308 patients who lost at least 10% of their body weight over a 36-week period before switching to a placebo for an additional 52 weeks.
Surprisingly, the findings revealed that nearly 82% of participants regained 25% or more of their initial weight reduction just one year after stopping Mounjaro. Furthermore, greater weight regain was associated with a notable reversal in other health benefits, including waist circumference, levels of "bad" cholesterol, blood pressure, and blood glucose levels.
"The findings are not surprising, as excess weight is a well-established driver of elevated blood pressure and impaired glucose control," noted Naveed Sattar, professor of cardiometabolic medicine at the University of Glasgow. "Consequently, when weight lost through therapeutic interventions is regained, these cardiometabolic risk factors typically rise in proportion to the speed and extent of weight regain."
The study emphasizes the importance of long-term maintenance of weight reduction through lifestyle intervention and obesity management medications to sustain cardiometabolic benefits and improved health-related quality of life. It also highlights the potential risks of relying solely on medication for weight loss, particularly when it can lead to poorer dietary habits and a lack of motivation to engage in regular physical activity.
While researchers acknowledge that further trials are necessary to confirm these findings, they underscore the need for caution and careful consideration when interpreting data related to weight-loss medications and their effects on health.
so i was taking mounjaro for like 3 months to lose weight and it was working amazing but then i stopped taking it and my weight went up by like 5kg 
it's wild how our bodies can just go back to old habits if we stop using the medication right? 
and now i'm thinking of starting a diet plan again... maybe i'll stick to it this time 
mounjaro might be effective in short term but what's the point if you just end up back at square one? and it's not like it's some sort of magic pill, it's just a medication. all this hype around weight loss is just setting people up for disappointment when reality hits 
. I'm not surprised, though - excess weight is a big deal for heart health and all that jazz. But still, it's kinda scary how easily we can just stop using these medications and lose everything we gained 
. it's like, our bodies are complex, right? we need lifestyle changes to actually see lasting results 
. i mean, what's the point of losing weight if you're just gonna regain it all? 
anyway, this study should give people pause when thinking about relying too heavily on meds for weight loss 
we need a more holistic approach to health 
. I mean, who'd expect that stopping a medication that's supposed to help you lose weight would just make you gain it all back? It sounds like the body just adapts or something... but 82% of people regaining 25% or more of their weight loss in just one year? That's pretty alarming. I need to see some more data on this, like what kind of diet and exercise support these people were doing while taking Mounjaro, and how long they'd been taking it before stopping... maybe that's the key to understanding why they didn't hold onto their weight loss? Sources, anyone? 
. It's like, what's the point? I mean, I'm glad people can get help with their weight, but we gotta be careful not to rely on meds alone 
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... it was like, so fake back then 
. But now we got Mounjaro, and it's like, "Hey, this is real! You can actually lose weight and feel good!" 
. But at what cost? We gotta be careful not to fall into the same traps as before 
.
. I mean, think about it, if you're relying solely on Mounjaro for 20 years, that's just not sustainable. It's like, what happens when the meds stop working? You're still gonna be obese and have all these health issues 
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And not only that, but my health gets worse too? That's a lot of pressure to deal with, you know? 
what's even crazier is they regained waist circumference, bad cholesterol, blood pressure... it's like their health just reset to normal 
Like, I know people who stopped using those sugar-free gum thingies and suddenly they'd have like 10 extra packs of regular gum just lying around... it's all about the willpower, right? 
. We need to focus on sustainable weight loss methods that aren't just relying on medication for quick fixes. Lifestyle changes are key, fam!
. Don't be all lazy and think you can just lose weight and then gain it back and expect to feel the same way 
. It's not worth it, fam. Get your priorities straight and make some lifestyle changes if you wanna stay healthy 
It's like, don't get me wrong, Mounjaro can be helpful, but you gotta think about the bigger picture here. Lifestyle changes are key... 
i mean dont get me wrong, eli lilly makes a pretty penny off this stuff 
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. You gotta put in the work if you want to keep it off 
.