Researchers tracking participants in a clinical trial have found that once people stop taking Mounjaro, a popular medication for weight loss, they not only regain weight but also see their other health benefits reverse.
The study's lead authors analyzed data from 308 individuals who had lost at least 10% of their body weight on the medication, alongside diet and exercise support. These participants were then randomly assigned to continue taking Mounjaro or switch to a placebo for another 52 weeks.
One year after stopping the medication, nearly 82% of these participants regained more than half of the initial weight they had lost. Notably, this weight regain was associated with a reversal in other health benefits as well, including reduced blood pressure and lower levels of "bad" cholesterol.
Experts say that excess weight is often a major driver of high blood pressure and impaired glucose control, so when people regain weight, these health risks typically increase. The findings suggest that sustaining weight loss through long-term lifestyle changes and obesity management medications is crucial to maintaining health benefits.
The study's lead authors note that while weight-regain was most pronounced in those who had lost the greatest amount of weight on Mounjaro, even smaller amounts of regain were still associated with some reversal of health improvements. This emphasizes the importance of long-term maintenance strategies for weight loss and overall health.
However, researchers caution that stopping weight-loss medications does not always lead to healthier eating habits or exercise routines. When people discontinue taking these medications, they often revert to their previous behaviors, which can result in weight regain and a reversal of other health benefits.
The findings have implications for those who are considering using Mounjaro or other weight loss medications, particularly in the context of pregnancy. While researchers found that women who stop using these medications before becoming pregnant tend to gain more weight during pregnancy and face higher risks of complications, further trials are needed to confirm these findings.
The study's lead authors analyzed data from 308 individuals who had lost at least 10% of their body weight on the medication, alongside diet and exercise support. These participants were then randomly assigned to continue taking Mounjaro or switch to a placebo for another 52 weeks.
One year after stopping the medication, nearly 82% of these participants regained more than half of the initial weight they had lost. Notably, this weight regain was associated with a reversal in other health benefits as well, including reduced blood pressure and lower levels of "bad" cholesterol.
Experts say that excess weight is often a major driver of high blood pressure and impaired glucose control, so when people regain weight, these health risks typically increase. The findings suggest that sustaining weight loss through long-term lifestyle changes and obesity management medications is crucial to maintaining health benefits.
The study's lead authors note that while weight-regain was most pronounced in those who had lost the greatest amount of weight on Mounjaro, even smaller amounts of regain were still associated with some reversal of health improvements. This emphasizes the importance of long-term maintenance strategies for weight loss and overall health.
However, researchers caution that stopping weight-loss medications does not always lead to healthier eating habits or exercise routines. When people discontinue taking these medications, they often revert to their previous behaviors, which can result in weight regain and a reversal of other health benefits.
The findings have implications for those who are considering using Mounjaro or other weight loss medications, particularly in the context of pregnancy. While researchers found that women who stop using these medications before becoming pregnant tend to gain more weight during pregnancy and face higher risks of complications, further trials are needed to confirm these findings.
! You'd think that just stopping taking Mounjaro would be enough to keep the weight loss going, but nope! It's like your body is all, "Nah, we good" 
. And not only do you regain weight, but your other health benefits too? That's just crazy talk 
. I mean, who needs a study to tell us that excess weight is bad for our health? It's like, duh! 
But seriously, this study highlights the importance of long-term lifestyle changes and obesity management medications. You can't just rely on medication alone, you need to make those healthy habits stick 
. And let's be real, it's not all about willpower, there needs to be more research on how to maintain weight loss without relying on meds 
.
"The biggest risk is not taking any risk" 
. You gotta be willing to try new things and take a chance on your health... even if it means trying meds like Mounjaro. It's all about finding that balance between losing weight and maintaining those health benefits long-term 
You're right back where you started. And not just that, you also start to regain health benefits that were amazing while you were taking the meds? Like, blood pressure starts rising again and cholesterol levels go through the roof 
. It's like your body forgets all the good things you achieved on the medication. The study says even if you lost a little weight, you're still gonna see some of those health benefits flip around. It just goes to show how hard it is to maintain weight loss and keep those health benefits going in the long run 
This is crazy! I mean, who wants to lose weight just to gain it all back? It's like the medication is helping you lose weight, but not actually changing your habits or behavior. That's so frustrating. And now we know that stopping Mounjaro can even reverse the health benefits, which is really scary. We need to find a way to make sustainable lifestyle changes stick, you know? 
Anyway, it makes sense that sustaining lifestyle changes is key to maintaining health benefits. But what about all us who can't even afford or access these medications? That's just not fair 
I'm literally shocked by this study! I mean, we all know it's hard to keep the weight off, but to see people not only regain weight but also have their health benefits reverse is just crazy. I've seen so many friends try to lose weight and struggle to maintain it, and this study just confirms what we all already knew - it's not easy! 
. It's so hard to maintain that progress, you know? 
? Just thinking about it makes me want to support people who are on this journey and remind them they're not alone 
. For real tho, losing weight is hard enough, but keeping it off? That's a whole different story. It's like the plot twist in Inception - things don't always go as planned 
and then they just gain it all back and some... its like their body is all "nope we dont wanna be healthy anymore" 
... like, you lose weight, feel better, but then when you stop the meds, all that progress goes out the window 
. It makes sense that our bodies just go back to being the way they were before we lost weight, but it's still kinda scary. I think this study highlights how important it is to find sustainable ways to lose weight and stay healthy - like, lifestyle changes and stuff 
and i totally feel for the women who are pregnant and need to be on these meds, but at the same time, we need more research on how long term effects play out 
. It's like our bodies just forget how to be healthy in the first place 
.
. It's like thinking you can just switch off your health goals and everything will be fine 
. Newsflash: it's not that easy 
. You gotta keep pushing yourself with healthy habits if you want to see real results.
. And what really gets me is that they say stopping the medication doesn't always lead to healthier habits... like, come on guys! If you want to keep the weight off, you gotta put in the work 
. You still gotta take care of yourself and make healthy choices. And yeah, it's always better to be safe than sorry... especially when pregnancy is involved 
. More studies need to be done on that front, for sure 
.
that's a major problem. gotta keep an eye on this one, especially for preggo women...