Lithium levels in drinking water may be linked to an increased risk of autism spectrum disorder (ASD) in children born to mothers exposed to higher concentrations during pregnancy. A new study published in the journal JAMA Pediatrics found a modest association between lithium exposure and ASD diagnosis, but experts caution that the connection is not conclusive.
The study analyzed data from 8,842 cases of ASD and 43,864 participants without ASD, comparing the concentration of lithium in drinking water to the risk of ASD diagnosis. The researchers found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children born to mothers exposed to higher levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure.
However, experts say more research is needed to confirm this association and rule out other factors that may contribute to the development of ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a professor of neurology at UCLA. "We need to replicate these findings in other countries to look for a similar connection."
The implications of this study are complex and far-reaching. While lithium has been linked to health benefits such as lower rates of hospitalization for psychiatric disorders and suicide, the potential risks of exposure through drinking water must be carefully considered. "If all these associations are valid, we will need to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology at Harvard Medical School.
Other studies have suggested connections between ASD and environmental exposures to pesticides, air pollution, and phthalates, but none have established these factors as direct causes of the disorder. As one expert noted, "we are bombarded with a variety of environmental stressors in our everyday lives, and we need to figure out how to safely navigate them."
The study's findings highlight the need for further research into the potential links between environmental exposures and ASD. While the connection between lithium exposure and ASD is intriguing, it remains unclear whether this association can be replicated and translated into meaningful public health policy.
The study analyzed data from 8,842 cases of ASD and 43,864 participants without ASD, comparing the concentration of lithium in drinking water to the risk of ASD diagnosis. The researchers found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children born to mothers exposed to higher levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure.
However, experts say more research is needed to confirm this association and rule out other factors that may contribute to the development of ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a professor of neurology at UCLA. "We need to replicate these findings in other countries to look for a similar connection."
The implications of this study are complex and far-reaching. While lithium has been linked to health benefits such as lower rates of hospitalization for psychiatric disorders and suicide, the potential risks of exposure through drinking water must be carefully considered. "If all these associations are valid, we will need to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology at Harvard Medical School.
Other studies have suggested connections between ASD and environmental exposures to pesticides, air pollution, and phthalates, but none have established these factors as direct causes of the disorder. As one expert noted, "we are bombarded with a variety of environmental stressors in our everyday lives, and we need to figure out how to safely navigate them."
The study's findings highlight the need for further research into the potential links between environmental exposures and ASD. While the connection between lithium exposure and ASD is intriguing, it remains unclear whether this association can be replicated and translated into meaningful public health policy.